Devices and methods useful for manipulating tools at a surgical site are disclosed. The disclosed devices and methods can be useful, for example, for orbiting the distal end of one tool around the distal end of another tool, such as in an endoscopic resection procedure, and/or for rotating a tool or an end effector. In one exemplary embodiment, an endoscopic device is provided and can include an elongate shaft having a first lumen and a second lumen formed therein, each of the first and the second lumens adapted to receive a tool therethrough. A rotatable element can be disposed at a distal end of the elongate shaft, the rotatable element having a lumen formed therein that is associated with the first lumen of the elongate shaft and also having a tool guide that is adapted to receive a tool and that is associated with the second lumen of the elongate shaft. The rotatable element can be configured to rotate on a longitudinal axis thereof such that the tool guide orbits the longitudinal axis of the rotatable element.