Invention Grant
- Patent Title: Simplified and improved method for preparing an antibody or an antibody fragment targeted immunoliposome for systemic administration of a therapeutic or diagnostic agent
- Patent Title (中): 用于制备用于全身施用治疗剂或诊断剂的抗体或抗体片段靶向免疫脂质体的简化和改进的方法
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Application No.: US10113927Application Date: 2002-04-02
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Publication No.: US07780882B2Publication Date: 2010-08-24
- Inventor: Esther H. Chang , Kathleen F. Pirollo
- Applicant: Esther H. Chang , Kathleen F. Pirollo
- Applicant Address: US DC Washington
- Assignee: Georgetown University
- Current Assignee: Georgetown University
- Current Assignee Address: US DC Washington
- Agency: Fanelli Strain & Haag PLLC
- Main IPC: B01J13/02
- IPC: B01J13/02 ; B01J13/04 ; A61K9/127 ; A61K39/00 ; A61K39/395
Abstract:
A method of preparing an antibody- or antibody fragment-targeted cationic immunoliposome or polymer complex comprises the steps of (a) preparing an antibody or antibody fragment; (b) mixing said antibody or antibody fragment with a cationic liposome to form a cationic immunoliposome or with a cationic polymer to form a polyplex; and (c) mixing said cationic immunoliposome or said polyplex with a therapeutic or diagnostic agent to form said antibody- or antibody fragment-targeted cationic immunoliposome or polymer complex.
Public/Granted literature
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