Invention Grant
- Patent Title: Targets for tumor growth inhibition
- Patent Title (中): 靶向肿瘤生长抑制
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Application No.: US10551667Application Date: 2004-04-01
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Publication No.: US07781414B2Publication Date: 2010-08-24
- Inventor: Patrick Y. Lu , Frank Y. Xie , Martin C. Woodle , Yijia Liu , Quinn Q. Tang , Jun Xu
- Applicant: Patrick Y. Lu , Frank Y. Xie , Martin C. Woodle , Yijia Liu , Quinn Q. Tang , Jun Xu
- Applicant Address: US CA Palo Alto
- Assignee: Intradigm Corporation
- Current Assignee: Intradigm Corporation
- Current Assignee Address: US CA Palo Alto
- Agency: Ropes & Gray LLP
- Agent Jane T. Gunnison; Alla Brukman
- International Application: PCT/US2004/010059 WO 20040401
- International Announcement: WO2004/089284 WO 20041021
- Main IPC: A61K31/70
- IPC: A61K31/70 ; C07H21/04 ; C07H21/00 ; C12P19/34
Abstract:
The present invention relates to methods for treating cancers by manipulating a target gene expression by up-regulation, silencing and/or down-regulation of the gene, such as EGFR-RP, TRA1, MFGE8, TNFSF13 and ZFP236, respectively. The methods are useful in treating cancers and/or inhibiting tumor growth by enhancing expression of a gene that is validated as a target such as ICT1030, for protein, peptide drug and gene therapy modalities; or by RNA interference to silence and/or down-regulate targets such as ICT1024, ICT1025 and ICT1031 and ICB1003 that are validated for antibody, small molecule and other inhibitor drug modalities.
Public/Granted literature
- US20070003519A1 Targets for tumor growth inhibition Public/Granted day:2007-01-04
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