Invention Grant
- Patent Title: Process for delivering sirna to cardiac muscle tissue
- Patent Title (中): 将精神神经递送至心肌组织的过程
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Application No.: US10770588Application Date: 2004-02-03
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Publication No.: US07781415B2Publication Date: 2010-08-24
- Inventor: Hans Herweijer , Julia Hegge , Jon A. Wolff , David L. Lewis
- Applicant: Hans Herweijer , Julia Hegge , Jon A. Wolff , David L. Lewis
- Applicant Address: US WI Madison
- Assignee: Roche Madison Inc.
- Current Assignee: Roche Madison Inc.
- Current Assignee Address: US WI Madison
- Agent Kirk Ekena
- Main IPC: A61K48/00
- IPC: A61K48/00
Abstract:
A process for delivering a polynucleotide to a cardiac tissue cell in a mammal is described, comprising introducing a composition consisting of a polynucleotide into a blood vessel and increasing permeability of the blood vessel to the polynucleotide. The polynucleotide can be a small interfering RNA or microRNA and inhibit gene expression in the cell.
Public/Granted literature
- US20040157790A1 Process for delivering sirna to cardiac muscle tissue Public/Granted day:2004-08-12
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