Invention Grant
- Patent Title: Indol-3-y-carbonyl-piperidin and piperazin-derivatives
- Patent Title (中): 吲哚-3-基羰基 - 哌啶和哌嗪衍生物
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Application No.: US11492312Application Date: 2006-07-25
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Publication No.: US07781436B2Publication Date: 2010-08-24
- Inventor: Caterina Bissantz , Christophe Grundschober , Hasane Ratni , Mark Rogers-Evans , Patrick Schnider
- Applicant: Caterina Bissantz , Christophe Grundschober , Hasane Ratni , Mark Rogers-Evans , Patrick Schnider
- Applicant Address: US NJ Nutley
- Assignee: Hoffmann-La Roche Inc.
- Current Assignee: Hoffmann-La Roche Inc.
- Current Assignee Address: US NJ Nutley
- Agent George W. Johnston; Patricia S. Rocha-Tramaloni; Kimberly J. Prior
- Priority: EP05107044 20050729; EP05111072 20051122
- Main IPC: A61K31/4985
- IPC: A61K31/4985 ; A61K31/454 ; A61K31/497 ; A61K31/506 ; C07D401/06 ; C07D401/14 ; C07D405/14 ; C07D487/04 ; C07D209/42 ; C07D209/22
Abstract:
The present invention relates to indol-3-yl-carbonyl-piperidin and piperazin derivatives which act as V1a receptor antagonists and which are represented by Formula I: wherein the residues R1 to R3 are as defined herein. The invention also relates to pharmaceutical compositions containing such compounds, and methods for preparation of the compounds and compositions. The invention further relates to methods for treating dysmenorrhea, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver cirrhosis, nephrotic syndrome, obsessive compulsive disorder, anxiety and depressive disorders.
Public/Granted literature
- US20070027163A1 Indol-3-y-carbonyl-piperidin and piperazin-derivatives Public/Granted day:2007-02-01
Information query
IPC分类:
