Invention Grant
US07781460B2 Substituted indazoles as inhibitors of phosphodiesterase type-IV
失效
取代的吲唑作为IV型磷酸二酯酶的抑制剂
- Patent Title: Substituted indazoles as inhibitors of phosphodiesterase type-IV
- Patent Title (中): 取代的吲唑作为IV型磷酸二酯酶的抑制剂
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Application No.: US12065819Application Date: 2006-08-30
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Publication No.: US07781460B2Publication Date: 2010-08-24
- Inventor: Venkata Palle , Sarala Balachandran , Lalit Kumar Baregama , Saswati Chakladar , Sarika Ramnani , Nagarajan Muthukamal , Abhijit Ray , Sunanda G. Dastidar
- Applicant: Venkata Palle , Sarala Balachandran , Lalit Kumar Baregama , Saswati Chakladar , Sarika Ramnani , Nagarajan Muthukamal , Abhijit Ray , Sunanda G. Dastidar
- Applicant Address: IN New Delhi
- Assignee: Ranbaxy Laboratories Limited
- Current Assignee: Ranbaxy Laboratories Limited
- Current Assignee Address: IN New Delhi
- Agent James J. DeYonker, Esq
- Priority: IN2378/DEL/2005 20050905
- International Application: PCT/IB2006/002369 WO 20060830
- International Announcement: WO2007/029077 WO 20070315
- Main IPC: A61K31/443
- IPC: A61K31/443 ; A61K31/416 ; A61K31/422 ; A61K31/427 ; C07D413/04 ; C07D271/06 ; C07D271/10 ; C07D261/04
Abstract:
The present invention relates to isoxazoline derivatives of structure Ia, which can be used as selective inhibitors of phosphodiesterase (PDE) type IV. Compounds disclosed herein can be useful in the treatment of CNS disorders, AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases especially in humans. Processes for the preparation of disclosed compounds are provided, as well as pharmaceutical compositions containing the disclosed compounds, and their use as phosphodiesterase (PDE) type IV inhibitors.
Public/Granted literature
- US20080312285A1 Substituted Indazoles as Inhibitors of Phosphodiesterase Type-Iv Public/Granted day:2008-12-18
Information query
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