Invention Grant
US07781642B2 Animal model having a chimeric human liver and susceptible to human hepatitis C virus infection
有权
具有嵌合人肝脏并易受人类丙型肝炎病毒感染的动物模型
- Patent Title: Animal model having a chimeric human liver and susceptible to human hepatitis C virus infection
- Patent Title (中): 具有嵌合人肝脏并易受人类丙型肝炎病毒感染的动物模型
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Application No.: US12333002Application Date: 2008-12-11
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Publication No.: US07781642B2Publication Date: 2010-08-24
- Inventor: Norman M. Kneteman , D. Lorne Tyrrell , David Frederick Mercer
- Applicant: Norman M. Kneteman , D. Lorne Tyrrell , David Frederick Mercer
- Applicant Address: CA Edmonton, Alberta
- Assignee: KMT Hepatech, Inc.
- Current Assignee: KMT Hepatech, Inc.
- Current Assignee Address: CA Edmonton, Alberta
- Agency: Bozicevic, Field & Francis, LLP
- Agent Carol L. Francis
- Main IPC: G01N33/00
- IPC: G01N33/00 ; A01K67/027
Abstract:
The present invention features a non-human animal model that is susceptible to infection by human hepatotrophic pathogens, particularly human hepatitis C virus (HCV). The model is based on a non-human, immunocompromised transgenic animal having a human-mouse chimeric liver, where the transgene provides for expression of a urokinase-type plasminogen activator in the liver. The invention also features methods for identifying candidate therapeutic agents, e.g., agents having antiviral activity against HCV infection. The animals of the invention are also useful in assessing toxicity of various agents, as well as the activity of agents in decreasing blood lipids.
Public/Granted literature
- US20090151012A1 Animal Model Having a Chimeric Human Liver and Susceptible to Human Hepatitis C Virus Infection Public/Granted day:2009-06-11
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