A non-volatile memory disposed on a substrate includes active regions, a memory array, and contacts. The active regions defined by isolation structures disposed in the substrate are extended in a first direction. The memory array is disposed on the substrate and includes memory cell columns, control gate lines and select gate lines. Each of the memory cell columns includes memory cells connected to one another in series and a source/drain region disposed in the substrate outside the memory cells. The contacts are disposed on the substrate at a side of the memory array and arranged along a second direction. The second direction crosses over the first direction. Each of the contacts extends across the isolation structures and connects the source/drain regions in the substrate at every two of the adjacent active regions.