A system for and method of determining calibration parameters while only capturing a single image is described herein. Furthermore, traditional calibration algorithms are avoided by the direct determination of the calibration parameters. The determination of the calibration parameters is possible by first determining a training data set from images acquired of a variety of objects with a multitude of colors. Then, using the training data set, regression coefficients are generated. A camera to be calibrated then acquires only one set of image information such as a single picture. Then, using the regression coefficients and the acquired information, the calibration parameters are directly estimated for that camera.