An electrostatic discharge protection device includes a power supply line and a ground line. A voltage detection unit detects first and second detection voltages by forming an electrical connection between the power supply line and the ground line in response to alternating current of electrostatic current. A first transfer unit transfers the electrostatic current into the power supply line by forming an electrical connection between the input/output pad and the power supply line in response to the first detection voltage. A second transfer unit transfers the electrostatic current into the ground line by forming an electrical connection between the input/output pad and the ground line in response to the second detection voltage. A discharge unit discharges the electrostatic current flowing into the power supply line or the ground line by forming an electrical connection between the power supply line and the ground line in response to the second detection voltage.