A tamper-evident, re-closable container is disclosed, comprising a container body, having a neck portion with a cammed projection, and a mouth rimmed by a lip and a closure having a top portion with a groove to rotatably engage and seal against the lip of the container, and a bottom portion having a contour formed therein to rest under the cammed projection. A breakable tamper-evident section circumferentially connects the top portion of the container to the bottom portion of the container and connecting means connects the top portion to the bottom portion. Rotation of the closure around the mouth of the container causes the cammed projection to force the bottom portion downwardly to break the tamper-evident section. A tamper-evident closure is also described for use with a re-closable container, having a top portion that can be rotated around a mouth of the container to cause a tamper-evident section to break.