An endoscopic therapeutic instrument has a therapeutic section, a flexible transmission member which transmits operating driving forces to the therapeutic section by moving forwardly and reversely, and a sheath section in which the transmission member can move forwardly and reversely. A proximal side of this transmission member is connected to an operating tube section, and the therapeutic section is driven by forward and backward movements of the operating tube section. An endoscope having a channel into which the endoscopic therapeutic instrument is insertable, contains a mechanism for driving the sheath section and a mechanism for driving the operating tube section. The endoscope controls these mechanisms to cooperate with each other in controlling the endoscopic therapeutic instrument operations.