Invention Grant
- Patent Title: Duplexed parvovirus vectors
- Patent Title (中): 双相细小病毒载体
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Application No.: US11655520Application Date: 2007-01-19
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Publication No.: US07790154B2Publication Date: 2010-09-07
- Inventor: Richard Jude Samulski , Douglas M. McCarty
- Applicant: Richard Jude Samulski , Douglas M. McCarty
- Applicant Address: US NC Chapell Hill
- Assignee: The University of North Carolina at Chapel Hill
- Current Assignee: The University of North Carolina at Chapel Hill
- Current Assignee Address: US NC Chapell Hill
- Agency: Myers Bigel Sibley & Sajovec, PA
- Main IPC: C12N15/86
- IPC: C12N15/86 ; C12N15/00 ; C12N15/64 ; A61K48/00
Abstract:
The present invention provides duplexed parvovirus vector genomes that are capable under appropriate conditions of forming a double-stranded molecule by intrastrand base-pairing. Also provided are duplexed parvovirus particles comprising the vector genome. Further disclosed are templates and methods for producing the duplexed vector genomes and duplexed parvovirus particles of the invention. Methods of administering these reagents to a cell or subject are also described. Preferably, the parvovirus capsid is an AAV capsid. It is further preferred that the vector genome comprises AAV terminal repeat sequences.
Public/Granted literature
- US20070110724A1 Duplexed parvovirus vectors Public/Granted day:2007-05-17
Information query
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