Invention Grant
US07790155B2 Calbindin-D28K protection against glucocorticoid induced cell death
有权
卡布林丁-D28K保护免受糖皮质激素诱导的细胞死亡
- Patent Title: Calbindin-D28K protection against glucocorticoid induced cell death
- Patent Title (中): 卡布林丁-D28K保护免受糖皮质激素诱导的细胞死亡
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Application No.: US11177790Application Date: 2005-07-08
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Publication No.: US07790155B2Publication Date: 2010-09-07
- Inventor: Sylvia Christakos , Yan Liu , Teresita Bellido
- Applicant: Sylvia Christakos , Yan Liu , Teresita Bellido
- Applicant Address: US NJ New Brunswick
- Assignee: University of Medicine and Dentistry of New Jersey
- Current Assignee: University of Medicine and Dentistry of New Jersey
- Current Assignee Address: US NJ New Brunswick
- Agency: Licata & Tyrrell P.C.
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C12N15/867 ; C12N15/861 ; C12N15/86
Abstract:
The present invention provides novel compositions containing a calbindin-D28k therapeutic element, which is involved in the regulation of apoptosis, and may be administered for the prevention of an abnormal apoptosis response in cells. In particular the compositions and methods of the present invention may be used for the prevention or induction of apoptosis in such cells types as osteoblasts and osteocytes. Specifically, the compositions and methods of the present invention are useful for the prevention of diseases associated with glucocorticoid induced cell death. Specifically, the compositions and methods of the present invention may be useful in the prevention of glucocorticoid induced cell death in osteoblasts and the treatment of such conditions as glucocorticoid induced osteoporosis.
Public/Granted literature
- US20050271627A1 Calbindin-D28K protection against glucocorticoid induced cell death Public/Granted day:2005-12-08
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