Invention Grant
US07790156B2 Δ-8 desaturases and their use in making polyunsaturated fatty acids 有权
&Dgr; -8去饱和酶及其在制备多不饱和脂肪酸中的应用

Δ-8 desaturases and their use in making polyunsaturated fatty acids
Abstract:
The present invention relates to Δ8 desaturase genes, which have the ability to convert eicosadienoic acid (EDA; 20:2 ω-6) to dihomo-γ-linolenic acid (DGLA; 20:3 ω-6) and/or eicosatrienoic acid (ETrA; 20:3 ω-3) to eicosatetraenoic acid (ETA; (20:3 ω-3). Isolated nucleic acid fragments and recombinant DNA constructs comprising such fragments encoding Δ8 desaturases along with a method of making long-chain polyunsaturated fatty acids (PUFAs) using these Δ8 desaturases in oleaginous yeast are disclosed.
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