Invention Grant
US07790177B2 Immunizing compositions comprising recombinant attenuated self-replicating viral RNA replicons encoding an epitope obtained from the HIV-1 matrix protein myrstate binding site
有权
免疫组合物，其包含编码从HIV-1基质蛋白淀粉状结合位点获得的表位的重组减毒自复制病毒RNA复制子
- Patent Title: Immunizing compositions comprising recombinant attenuated self-replicating viral RNA replicons encoding an epitope obtained from the HIV-1 matrix protein myrstate binding site
- Patent Title (中): 免疫组合物，其包含编码从HIV-1基质蛋白淀粉状结合位点获得的表位的重组减毒自复制病毒RNA复制子
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Application No.: US12229865Application Date: 2008-08-27
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Publication No.: US07790177B2Publication Date: 2010-09-07
- Inventor: Nelson M. Karp
- Applicant: Nelson M. Karp
- Agency: Williams Mullen
- Agent Kelly J. Hollowell
- Main IPC: A61K39/12
- IPC: A61K39/12 ; A61K39/21 ; A61K39/193 ; C07H21/04
Abstract:
The present invention relates to an immunogenic composition. More particularly, the present invention is a composition directed to eliciting an immune response to at least one covalent binding site of myristate (SEQ ID NOS: 1-3) on the HIV matrix protein. The present invention contemplates three categories of embodiments: protein or protein fragments (SEQ ID NO: 1), messenger RNA, or DNA/RNA (SEQ ID NOS:2-3). DNA/RNA compositions may be either naked or recombinant. The present invention further contemplates use with a variety of immune stimulants.
Public/Granted literature
- US20090028890A1 Immunogenic composition and method of developing a vaccine based on portions of the HIV matrix protein Public/Granted day:2009-01-29
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