Invention Grant
US07790417B2 Stable biodegradable, high water absorbable polyglutamic acid hydrogel by 3-dimensional cross-linking and its preparation method
有权
通过三维交联稳定的可生物降解,高吸水性聚谷氨酸水凝胶及其制备方法
- Patent Title: Stable biodegradable, high water absorbable polyglutamic acid hydrogel by 3-dimensional cross-linking and its preparation method
- Patent Title (中): 通过三维交联稳定的可生物降解,高吸水性聚谷氨酸水凝胶及其制备方法
-
Application No.: US12047765Application Date: 2008-03-13
-
Publication No.: US07790417B2Publication Date: 2010-09-07
- Inventor: Guan-Heui Ho , Tou-Hsiung Yang , Kung-Hsiang Yang
- Applicant: Guan-Heui Ho , Tou-Hsiung Yang , Kung-Hsiang Yang
- Applicant Address: TW Taichung Hsien
- Assignee: Tung Hai Biotechnology Corporation
- Current Assignee: Tung Hai Biotechnology Corporation
- Current Assignee Address: TW Taichung Hsien
- Agency: Scully, Scott, Murphy & Presser, P.C.
- Main IPC: C12P19/00
- IPC: C12P19/00 ; C12P19/44 ; C12P13/02

Abstract:
The present invention relates to a method for the production of a stable biodegradable, high water absorbable γ-polyglutamic acid (γ-PGA) hydrogel by directly cross-linking (A) a γ-polyglutamic acid (γ-PGA), a γ-polyglutamate, or a mixture thereof, and optionally a polysaccharide containing a carboxylic and/or carboxylate group, an amino acid, or a mixture thereof; and/or (B) a microbial culture broth containing a γ-polyglutamic acid (γ-PGA), a γ-polyglutamate, or a mixture thereof, and optionally a polysaccharide containing a carboxylic and/or carboxylate group, an amino acid, or a mixture thereof, with a cross-linker comprising a compound having three or more functional groups or a mixture of a compound having three or more functional groups and a compound having two functional groups, wherein each of the functional groups can react with a carboxylic group (—COOH), carboxylate group (—COO−), aldehyde group (—CHO), hydroxyl (—OH), carbonyl group (—CO), sulfone group (—SO2), amino group (—NH2) or nitro group (—NO2), or a mixture thereof. The present invention further relates to a stable biodegradable, high water absorbable γ-polyglutamic acid (γ-PGA) hydrogel and its uses.
Public/Granted literature
Information query