Invention Grant
US07790691B2 Double stranded compositions comprising a 3′-endo modified strand for use in gene modulation
有权
包含用于基因调控的3'-端修饰的链的双链组合物
- Patent Title: Double stranded compositions comprising a 3′-endo modified strand for use in gene modulation
- Patent Title (中): 包含用于基因调控的3'-端修饰的链的双链组合物
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Application No.: US10561324Application Date: 2004-06-03
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Publication No.: US07790691B2Publication Date: 2010-09-07
- Inventor: Bryan A. Kraynack , Brenda F. Baker , Balkrishen Bhat , Eric E. Swayze , Richard H. Griffey
- Applicant: Bryan A. Kraynack , Brenda F. Baker , Balkrishen Bhat , Eric E. Swayze , Richard H. Griffey
- Applicant Address: US CA Carlsbad
- Assignee: Isis Pharmaceuticals, Inc.
- Current Assignee: Isis Pharmaceuticals, Inc.
- Current Assignee Address: US CA Carlsbad
- Agency: ISIS Patent Department
- International Application: PCT/US2004/017487 WO 20040603
- International Announcement: WO2004/113496 WO 20041229
- Main IPC: A61K31/70
- IPC: A61K31/70 ; C07H21/04
Abstract:
The present invention provides double stranded compositions that have a region that is complementary to a target nucleic acid. One of the targeting strand or the second strand comprises linked ribofuranosyl nucleosides and the other strand comprises linked modified nucleosides that have 3′-endo conformational geometry. The strands can be linked together or separate and may contain additional groups. The present invention also provides methods of using the compositions for modulating gene expression.
Public/Granted literature
- US20070015722A1 Double stranded compositions comprising a 3'-endo modified strand for use in gene modulation Public/Granted day:2007-01-18
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