Invention Grant
US07790712B2 Substituted [1,4]diazepino[1,2-A]indoles and azepino[1,2-A]indoles as anti-cytokine inhibitors
有权
取代的[1,4]二氮杂[1,2-A]吲哚和氮杂环[1,2-A]吲哚作为抗细胞因子抑制剂
![Substituted [1,4]diazepino[1,2-A]indoles and azepino[1,2-A]indoles as anti-cytokine inhibitors](/docs/US/2010-09-07/US07790712B2/abs.jpg.600x600.jpg)
- Patent Title: Substituted [1,4]diazepino[1,2-A]indoles and azepino[1,2-A]indoles as anti-cytokine inhibitors
- Patent Title (中): 取代的[1,4]二氮杂[1,2-A]吲哚和氮杂环[1,2-A]吲哚作为抗细胞因子抑制剂
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Application No.: US11276935Application Date: 2006-03-17
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Publication No.: US07790712B2Publication Date: 2010-09-07
- Inventor: Derek Cogan , Donghong A. Gao , Daniel R. Goldberg , Craig Andrew Miller , Neil Moss , Matthew Russell Netherton , Philip Dean Ramsden , Zhaoming Xiong
- Applicant: Derek Cogan , Donghong A. Gao , Daniel R. Goldberg , Craig Andrew Miller , Neil Moss , Matthew Russell Netherton , Philip Dean Ramsden , Zhaoming Xiong
- Applicant Address: US CT Ridgefield
- Assignee: Boehringer Ingelheim Pharmaceutical, Inc.
- Current Assignee: Boehringer Ingelheim Pharmaceutical, Inc.
- Current Assignee Address: US CT Ridgefield
- Agent Michael P. Morris; Mary-Ellen M. Devlin; Edward S. Lazer
- Main IPC: C07D487/04
- IPC: C07D487/04 ; A61K31/519 ; C07D471/04 ; A61K31/4985 ; A61K31/5365 ; A61P37/06
![Substituted [1,4]diazepino[1,2-A]indoles and azepino[1,2-A]indoles as anti-cytokine inhibitors](/abs-image/US/2010/09/07/US07790712B2/abs.jpg.150x150.jpg)
Abstract:
The application relates to compounds of formula Ia and analogues thereof wherein R1 to R13 and X are as defined herein. The invention also relates to the use of the compounds of formula Ia as inhibitors of Mitogen-Activated Protein Kinase-Activated Protein kinase-2 (MAPKAP-k2), and also to a method for preventing or treating a disease or disorder that can be treated or prevented by modulating the activity of MAPKAP-K2 in a subject and to pharmaceutical compositions and kits that include these MAPKAP-K2 inhibitors.
Public/Granted literature
- US20060276453A1 Anti-Cytokine Heterocyclic Compounds Public/Granted day:2006-12-07
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