Invention Grant
- Patent Title: Compounds capable of activating cholinergic receptors
- Patent Title (中): 能够激活胆碱能受体的化合物
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Application No.: US11932895Application Date: 2007-10-31
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Publication No.: US07790757B2Publication Date: 2010-09-07
- Inventor: William Scott Caldwell , Gary Maurice Dull , Balwinder Singh Bhatti , Srishailkumar B. Hadimani , Haeil Park , Jared Miller Wagner , Peter Anthony Crooks
- Applicant: William Scott Caldwell , Gary Maurice Dull , Balwinder Singh Bhatti , Srishailkumar B. Hadimani , Haeil Park , Jared Miller Wagner , Peter Anthony Crooks
- Applicant Address: US NC Winston-Salem
- Assignee: Targacept, Inc.
- Current Assignee: Targacept, Inc.
- Current Assignee Address: US NC Winston-Salem
- Agency: Womble Carlyle Sandridge & Rice, PLLC
- Agent Amy H. Fix
- Main IPC: A61K31/44
- IPC: A61K31/44 ; A61P25/28 ; A61P25/18 ; C07D213/02 ; A61P25/16 ; A61P25/14
Abstract:
Compounds incorporating aryl substituted olefinic amine are provided. Representative compounds are (4E)-N-methyl-5-(3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-pyrimidinyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-methoxy-3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(6-amino-5-methyl-3-pyridyl)-4-penten-2-amine, (2R)-(4E)-N-methyl-5-(3-pyridyl)-4-penten-2-amine, (2R)-(4E)-N-methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-bromo-3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-ethoxy-3-pyridyl)-4-penten-2-amine, (2S)-(4E)-N-methyl-5-(3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine and (2S)-(4E)-N-methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine.
Public/Granted literature
- US20080214628A1 Compounds Capable of Activating Cholinergic Receptors Public/Granted day:2008-09-04
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