Invention Grant
US07790767B2 Pleuromutilin derivatives containing a hydroxyamino- or acyloxyaminocycloalkyl group
有权
含有羟基氨基或酰氧基氨基环烷基的曲美罗替丁衍生物
- Patent Title: Pleuromutilin derivatives containing a hydroxyamino- or acyloxyaminocycloalkyl group
- Patent Title (中): 含有羟基氨基或酰氧基氨基环烷基的曲美罗替丁衍生物
-
Application No.: US11814672Application Date: 2006-06-26
-
Publication No.: US07790767B2Publication Date: 2010-09-07
- Inventor: Rosemarie Mang , Gerd Ascher , Mathias Ferencic , Werner Heilmayer , Rodger Novak
- Applicant: Rosemarie Mang , Gerd Ascher , Mathias Ferencic , Werner Heilmayer , Rodger Novak
- Applicant Address: AT Vienna
- Assignee: Nabriva Therapeutics Forschungs GmbH
- Current Assignee: Nabriva Therapeutics Forschungs GmbH
- Current Assignee Address: AT Vienna
- Agency: Knobbs Martens Olson & Bear LLP
- Priority: GB0513060.4 20050627; GB0515997.5 20050803
- International Application: PCT/AT2006/000260 WO 20060626
- International Announcement: WO2007/000004 WO 20070104
- Main IPC: A61K31/215
- IPC: A61K31/215 ; C07C69/74
Abstract:
The present invention relates to Compounds of general formula (I), wherein R is hydrogen and R1 is hydroxy or acyloxy, or R is acyl and R1 is hydroxy or acyloxy, X is sulphur, oxygen or NR10, wherein R10 is hydrogen or (C1-4)alkyl; Y is sulphur or oxygen; R2 is hydrogen or one or more substituents, e.g. including substituents such as conventional in organic, e.g. (pleuro)mutilin, chemistry; R4 is hydrogen or (C1-4)alkyl; R5 is hydrogen or (C1-4)alkyl; R3 and R3′ are hydrogen, deuterium, or halogen; R6, R7 and R8 are hydrogen, halogen or deuterium; m is a number selected from 0 to 4, n is a number selected from 0 to 10, and p is a number selected from 0 to 10; with the proviso that n plus p are at least 1. These Compounds are usefül as pharmaceuticals, particularly as antimicrobials.
Public/Granted literature
- US20090306203A1 PLEUROMUTILIN DERIVATIVES CONTAINING A HYDROXYAMINO- OR ACYLOXYAMINOCYCLOALKYL GROUP Public/Granted day:2009-12-10
Information query
