An LCD driving circuit comprising an over-voltage protection circuit includes an input terminal to receive an input voltage, a voltage-dividing circuit, a voltage-stabilizing circuit including a voltage-stabilizing element, a control circuit, a switching element, and an output terminal. The voltage-dividing circuit provides a reference voltage according to the input voltage to the voltage-stabilizing circuit, the voltage-stabilizing circuit determines whether the voltage-stabilizing element conducts according to the reference voltage, and the control circuit controls the switching element to switch on or off according to a working stage of the voltage-stabilizing element to determine whether the output terminal outputs an output voltage.