A system and method for populating a database with a set of image sequences of an object is disclosed. The database is used to detect localization of a guidewire in the object. A set of images of anatomical structures is received in which each image is annotated to show a guidewire, catheter, wire tip and stent. For each given image a Probabilistic Boosting Tree (PBT) is used to detect short line segments of constant length in the image. Two segment curves are constructed from the short line segments. A discriminative joint shape and appearance model is used to classify each two segment curve. A shape of an n-segment curve is constructed by concatenating all the two segment curves. A guidewire curve model is identified that includes a start point, end point and the n-segment curve. The guidewire curve model is stored in the database.