Invention Grant
- Patent Title: Anti-amyloid β antibodies
- Patent Title (中): 抗淀粉样蛋白 抗体
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Application No.: US10505313Application Date: 2003-02-20
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Publication No.: US07794719B2Publication Date: 2010-09-14
- Inventor: Michael Bardroff , Bernd Bohrmann , Manfred Brockhaus , Walter Huber , Titus Kretzschmar , Hansruedi Loetscher , Corinna Löhning , Christer Nordstedt , Christine Rothe
- Applicant: Michael Bardroff , Bernd Bohrmann , Manfred Brockhaus , Walter Huber , Titus Kretzschmar , Hansruedi Loetscher , Corinna Löhning , Christer Nordstedt , Christine Rothe
- Applicant Address: CH Basel DE Martinsried
- Assignee: F. Hoffmann-La Roche AG,Morphosys AG
- Current Assignee: F. Hoffmann-La Roche AG,Morphosys AG
- Current Assignee Address: CH Basel DE Martinsried
- Agency: Bryan Cave LLP
- Priority: EP02003844 20020220
- International Application: PCT/EP03/01759 WO 20030220
- International Announcement: WO03/070760 WO 20030828
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/18

Abstract:
The present invention relates to antibody molecules capable of specifically recognizing two regions of the R-A4 peptide, wherein the first region comprises the amino acid sequence AEFRHDSGY as shown in SEQ ID NO: 1 or a fragment thereof and wherein the second region comprises the amino acid sequence VHHQKLVFFAEDVG as shown in SEQ ID NO: 2 or a fragment thereof. Furthermore, nucleic acid molecules encoding the inventive antibody molecules and vectors and hosts comprising said nucleic acid molecules are disclosed. In addition, the present invention provides for compositions, preferably pharmaceutical or diagnostic compositions, comprising the compounds of the invention as well as for specific uses of the antibody molecules, nucleic acid molecules, vectors or hosts of the invention.
Public/Granted literature
- US20050169925A1 Anti-amyloid beta antibodies and their use Public/Granted day:2005-08-04
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