Invention Grant
- Patent Title: Heterobicyclic metalloprotease inhibitors
- Patent Title (中): 异双环金属蛋白酶抑制剂
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Application No.: US12001043Application Date: 2007-12-07
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Publication No.: US07795245B2Publication Date: 2010-09-14
- Inventor: Christoph Steeneck , Christian Gege , Frank Richter , Heiko Kroth , Matthias Hochgurtel , Michael Essors , Joshua Van Veldhuizen , Bert Nolte , Brian M. Gallagher, Jr. , Tim Feuerstein , Matthias Schneider , Torsten Arndt , Hongbo Deng , Ralf Biesinger , Xinyuan Wu , Harald Bluhm , Irving Sucholeiki , Arthur G. Taveras
- Applicant: Christoph Steeneck , Christian Gege , Frank Richter , Heiko Kroth , Matthias Hochgurtel , Michael Essors , Joshua Van Veldhuizen , Bert Nolte , Brian M. Gallagher, Jr. , Tim Feuerstein , Matthias Schneider , Torsten Arndt , Hongbo Deng , Ralf Biesinger , Xinyuan Wu , Harald Bluhm , Irving Sucholeiki , Arthur G. Taveras
- Applicant Address: US CA Thousand Oaks
- Assignee: Atlantos Pharmaceuticals Holding, Inc.
- Current Assignee: Atlantos Pharmaceuticals Holding, Inc.
- Current Assignee Address: US CA Thousand Oaks
- Agent Elsa D. Lemoine
- Main IPC: A61K31/397
- IPC: A61K31/397 ; A61K31/519 ; A61K31/535 ; A01N43/90 ; C07D487/00 ; C07D413/00
Abstract:
The present invention relates generally to amide group containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibitor compounds having the following formulas: wherein R1, R2, R3, and R4 are as defined in the specification. More particularly, the present invention provides a new class of heterobicyclic MMP-13 inhibiting and MMP-3 inhibiting compounds amide containing heterobicyclic compounds, that exhibit an increased potency in relation to currently known MMP-13 and MMP-3 inhibitors.
Public/Granted literature
- US20090137547A1 Heterobicyclic metalloprotease inhibitors Public/Granted day:2009-05-28
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