Invention Grant
- Patent Title: Oxadiazole derivative as DGAT inhibitors
- Patent Title (中): 恶二唑衍生物作为DGAT抑制剂
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Application No.: US11792922Application Date: 2005-12-09
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Publication No.: US07795283B2Publication Date: 2010-09-14
- Inventor: Alan Martin Birch , Suzanne Saxon Bowker , Roger John Butlin , Craig Samuel Donald , William McCoull , Thorsten Nowak , Alleyn Plowright
- Applicant: Alan Martin Birch , Suzanne Saxon Bowker , Roger John Butlin , Craig Samuel Donald , William McCoull , Thorsten Nowak , Alleyn Plowright
- Applicant Address: SE Sodertalje
- Assignee: AstraZeneca AB
- Current Assignee: AstraZeneca AB
- Current Assignee Address: SE Sodertalje
- Agency: Morgan Lewis & Bockius LLP
- Priority: GB0427328.0 20041214; GB0507403.4 20050413; GB0520383.1 20051007
- International Application: PCT/GB2005/004726 WO 20051209
- International Announcement: WO2006/064189 WO 20060622
- Main IPC: A61K31/4245
- IPC: A61K31/4245 ; C07D271/113

Abstract:
Compounds of formula (I), and salts and pro-drugs thereof: Formula (I) wherein for example R1 is optionally substituted aryl or heteroaryl; Y is a linking group selected from, for example, a direct bond, and a (substituted) alkyl chain; R2 is an optionally substituted aryl, an optionally substituted cycloalkyl or an optionally substituted heterocyclic group; are described. Processes to make such compounds and their use as DGAT inhibitors, for example in the treatment of obesity, are also described.
Public/Granted literature
- US20080096874A1 Oxadiazole Derivative as Dgat Inhibitors Public/Granted day:2008-04-24
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