Invention Grant
- Patent Title: Histone deacetylase inhibitors
- Patent Title (中): 组蛋白脱乙酰酶抑制剂
-
Application No.: US11660718Application Date: 2005-08-22
-
Publication No.: US07795304B2Publication Date: 2010-09-14
- Inventor: Sandro Belvedere , Christopher Laurence Hamblett , Thomas A. Miller , David J. Witter , Jiaming Yan
- Applicant: Sandro Belvedere , Christopher Laurence Hamblett , Thomas A. Miller , David J. Witter , Jiaming Yan
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Li Su; David A Muthard
- International Application: PCT/US2005/029913 WO 20050822
- International Announcement: WO2006/026260 WO 20060309
- Main IPC: C07C271/20
- IPC: C07C271/20 ; C07D295/088 ; C07D277/46 ; C07D213/30 ; A61K31/5375 ; A61K31/4402 ; A61K31/4168 ; A61K31/40 ; A61K31/325
Abstract:
The invention relates to hydroxamic acid derivatives having carbamate linkage with the structural formula that are inhibitors of histone deacetylase (HDAC), and are useful in the prevention and/or treatment of cellular proliferative diseases, for example cancer, autoimmune, allergic and inflammatory diseases, diseases of the central nervous systems (CNS) such as neurodegenerative diseases, and in the prevention and/or treatment of restenosis.
Public/Granted literature
- US20090118291A1 Histone deacetylase inhibitors Public/Granted day:2009-05-07
Information query
