Invention Grant
- Patent Title: Carbamoyl esters that inhibit cholinesterase and release pharmacologically active agents
- Patent Title (中): 抑制胆碱酯酶并释放药理学活性剂的氨基甲酰酯
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Application No.: US10576861Application Date: 2004-10-19
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Publication No.: US07795307B2Publication Date: 2010-09-14
- Inventor: Jeroen C. Verheijen , ShouCheng Du
- Applicant: Jeroen C. Verheijen , ShouCheng Du
- Applicant Address: US NC Durham
- Assignee: CoLucid Pharmaceuticals, Inc.
- Current Assignee: CoLucid Pharmaceuticals, Inc.
- Current Assignee Address: US NC Durham
- Agency: Mintz, Levin, Cohn, Ferris, Glovsky & Popeo, P.C.
- Agent Ivor R. Elrifi; Heidi A. Erlacher
- International Application: PCT/US2004/034548 WO 20041019
- International Announcement: WO2005/042475 WO 20050512
- Main IPC: A61K31/216
- IPC: A61K31/216

Abstract:
Carbamoyl esters inhibit cholinesterase activity and, upon hydrolysis release a pharmacologically active agent. In one embodiment, the carbamoyl ester has the following structure: Formula (I) wherein A is selected from the group consisting of an unsubstituted aryl, a substituted aryl, an unsubstituted heteroaryl and a substituted heteroaryl. The carbamoyl esters are employed in methods to treat an individual. The pharmacologically active agent obtained by hydrolysis of the carbamoyl esters can treat, for example, a nervous system condition, a cholinergic deficiency and conditions or diseases associated with a deficiency in a pharmacologically active agent, such as acetylcholine.
Public/Granted literature
- US20070275959A1 Carbamoyl Esters That Inhibit Cholinesterase And Release Pharmacologically Active Agents Public/Granted day:2007-11-29
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