Invention Grant
US07795413B2 Nucleic acids encoding human anti-NGF neutralizing antibodies as selective NGF pathway inhibitors
有权
编码人抗NGF中和抗体的核酸作为选择性NGF途径抑制剂
- Patent Title: Nucleic acids encoding human anti-NGF neutralizing antibodies as selective NGF pathway inhibitors
- Patent Title (中): 编码人抗NGF中和抗体的核酸作为选择性NGF途径抑制剂
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Application No.: US11767326Application Date: 2007-06-22
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Publication No.: US07795413B2Publication Date: 2010-09-14
- Inventor: Kenneth D. Wild, Jr. , James J. S. Treanor , Haichun Huang , Heather Inoue , Tie J. Zhang , Frank Martin
- Applicant: Kenneth D. Wild, Jr. , James J. S. Treanor , Haichun Huang , Heather Inoue , Tie J. Zhang , Frank Martin
- Applicant Address: US CA Thousand Oaks
- Assignee: Amgen, Inc.
- Current Assignee: Amgen, Inc.
- Current Assignee Address: US CA Thousand Oaks
- Agency: McDonnell Boehen Hulbert & Berghoff
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C12N15/00 ; C12N5/06 ; A61K39/395 ; C12P21/08 ; C07K16/00
Abstract:
This invention provides antibodies that interact with or bind to human nerve growth factor (NGF) and neutralize the function of NGF thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing NGF function, and particularly for treating NGF-related disorders (e.g., chronic pain) by administering a pharmaceutically effective amount of anti-NGF antibodies. Methods of detecting the amount of NGF in a sample using anti-NGF antibodies are also provided.
Public/Granted literature
- US20080033157A1 HUMAN ANTI-NGF NEUTRALIZING ANTIBODIES AS SELECTIVE NGF PATHWAY INHIBITORS Public/Granted day:2008-02-07
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