Invention Grant
US07795463B2 Process for preparing diisopropyl((1-(hydroxymethyl)-cyclopropyl)oxy)methylphosphonate
失效
制备((1-(羟基甲基) - 环丙基)氧基)甲基膦酸二异丙酯的方法
- Patent Title: Process for preparing diisopropyl((1-(hydroxymethyl)-cyclopropyl)oxy)methylphosphonate
- Patent Title (中): 制备((1-(羟基甲基) - 环丙基)氧基)甲基膦酸二异丙酯的方法
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Application No.: US11631263Application Date: 2005-06-27
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Publication No.: US07795463B2Publication Date: 2010-09-14
- Inventor: Suk-Kyoon Yoon , Kun-Hye Nam , Sang-Who Lee , Won-Kyo Joung , Sang-Chul Choi , Ki-Kon Lee
- Applicant: Suk-Kyoon Yoon , Kun-Hye Nam , Sang-Who Lee , Won-Kyo Joung , Sang-Chul Choi , Ki-Kon Lee
- Applicant Address: KR Seoul
- Assignee: LG Life Sciences Ltd.
- Current Assignee: LG Life Sciences Ltd.
- Current Assignee Address: KR Seoul
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: KR10-2004-0051558 20040702
- International Application: PCT/KR2005/002007 WO 20050627
- International Announcement: WO2006/004330 WO 20060112
- Main IPC: C07F9/40
- IPC: C07F9/40 ; C07C43/164

Abstract:
Disclosed is a process for preparing a compound of the following formula (2): including the steps of reacting a compound of the following formula (4): with trityl chloride to prepare trityloxy-acetic acid ethyl ester of the following formula (8): reacting the compound of formula (8) with ethyl magnesium halide to prepare 1-trityloxymethyl-cyclopropanol of the following formula (9): combining the 1-trityloxymethyl-cyclopropanol of formula (9) with diisopropylbromo-methylphosphonate in a solvent in the presence of a base to prepare (1-trityloxymethyl-cyclopropoxymethyl)-phosphonic acid diisopropyl ester of the following formula (10): as a solid form, and converting the trityl group of the compound of formula (10) into a hydroxyl group.
Public/Granted literature
- US20090187019A1 Process for preparing diisopropyl((1-(hydroxymethyl)-cyclopropyl)oxy)methylphosphonate Public/Granted day:2009-07-23
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