An imager apparatus and methods are described. An embodiment of an imager module includes a plurality of groups of optical lenses, a lens frame, and at least one associated lens barrel configured to position and hold the plurality of groups of optical lenses. At least one of the groups of optical lenses is movable with respect to at least one other group of optical lenses for achieving optical focus. The imager module includes an integrated circuit (IC) imager die in proximity to the plurality of lenses, the imager die containing at least one image capture microelectronic device. The imager module includes a modular frame assembly that contains a first portion that holds a plurality of lens barrels, each containing one or more focusing lenses, and a second portion that supports the first portion at a specific distance from the substrate being imaged. The lens barrels are each responsive to different wavelengths or bands of wavelengths. The first and second portions include minimal, partial, or full partition structures between the imaging areas defined by the lens barrels.