In one embodiment, a spectral map for performing nonlinear calibration of a signal path is developed by 1) identifying a set of frequency locations for a set of particular output signal spurs that result from applying one-tone and two-tone input signals covering a bandwidth of interest to the signal path; 2) developing, based on the set of frequency locations, a spectral map for predistorting, in the frequency domain, signals that are applied to, or received from, the signal path in the time domain; and 3) saving the spectral map for performing nonlinear calibration of the signal path.