A method, system, and storage medium for computer aided processing of an image set includes employing a data source, the data source including an image set acquired from X-ray projection imaging, x-ray computed tomography, or x-ray tomosynthesis, defining a region of interest within one or more images from the image set, extracting feature measures from the region of interest, and reporting at least one of the feature measures on the region of interest. The method may be employed for identifying bone fractures, disease, obstruction, or any other medical condition.