A baric electromagnetic thermal system for manufacturing disaccharide sweetener compounds is provided and permits baric and thermal processing, at low temperatures, to effect the retrocycloaddition, chemoselective promiscuous ligation, and cycloaddition reactions. A method for selecting base and adjunct components for the manufacture of a disaccharide sweetener compound having an equivalent functionality as a natural sweetener and/or derivative thereof as required for a specific food processing application is presented.