Invention Grant
US07799345B2 Preparation of injectable suspensions having improved injectability
有权
具有改进的注射性的可注射悬浮液的制备
- Patent Title: Preparation of injectable suspensions having improved injectability
- Patent Title (中): 具有改进的注射性的可注射悬浮液的制备
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Application No.: US11826994Application Date: 2007-07-19
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Publication No.: US07799345B2Publication Date: 2010-09-21
- Inventor: Stephen E. Zale , J. Michael Ramstack , Joyce M. Hotz , M. Gary I. Riley , Olufunmi L. Johnson
- Applicant: Stephen E. Zale , J. Michael Ramstack , Joyce M. Hotz , M. Gary I. Riley , Olufunmi L. Johnson
- Applicant Address: US MA Waltham
- Assignee: Alkermes Controlled Therapeutics, Inc.
- Current Assignee: Alkermes Controlled Therapeutics, Inc.
- Current Assignee Address: US MA Waltham
- Agency: Covington & Burling LLP
- Agent Andrea G. Reister
- Main IPC: A61K9/14
- IPC: A61K9/14 ; A61K9/16

Abstract:
Injectable compositions having improved injectability. The injectable compositions include microparticles suspended in an aqueous injection vehicle having a viscosity of at least 20 cp at 20° C. The increased viscosity of the injection vehicle that constitutes the fluid phase of the suspension significantly reduces in vivo injectability failures. The injectable compositions can be made by mixing dry microparticles with an aqueous injection vehicle to form a suspension, and then mixing the suspension with a viscosity enhancing agent to increase the viscosity of the fluid phase of the suspension to the desired level for improved injectability.
Public/Granted literature
- US20080044485A1 Preparation of injectable suspensions having improved injectability Public/Granted day:2008-02-21
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