Invention Grant
US07799549B2 Methods for increasing protein polyethylene glycol (PEG) conjugation
有权
增加蛋白质聚乙二醇（PEG）缀合的方法
- Patent Title: Methods for increasing protein polyethylene glycol (PEG) conjugation
- Patent Title (中): 增加蛋白质聚乙二醇（PEG）缀合的方法
-
Application No.: US12001304Application Date: 2007-12-10
-
Publication No.: US07799549B2Publication Date: 2010-09-21
- Inventor: Shukuan Li , Zhijian Yang , Xinghua Sun , Yuying Tan , Shigeo Yagi
- Applicant: Shukuan Li , Zhijian Yang , Xinghua Sun , Yuying Tan , Shigeo Yagi
- Applicant Address: US CA San Diego
- Assignee: Anticancer, Inc.
- Current Assignee: Anticancer, Inc.
- Current Assignee Address: US CA San Diego
- Agency: Morrison & Foerster LLP
- Main IPC: C12N9/96
- IPC: C12N9/96 ; A61K38/43 ; G01N33/574
Abstract:
The present invention relates to highly conjugated proteins and methods for making such proteins. In particular, the present invention relates to methods for linking additional sites to a protein for conjugation with activated polyethylene glycol (PEG) linkers, without denaturing the protein. The invention also relates to highly conjugated proteins with decreased immunogenicity and increased circulating half-life.
Public/Granted literature
- US20080153740A1 Methods for increasing protein polyethylene glycol (PEG) conjugation Public/Granted day:2008-06-26
Information query
