Invention Grant
US07799770B2 Solid body forms of mesoprogestin 11β-{4E-(hydroxyiminomethyl)-phenyl}-17α methoxymethyl-17β-methoxy-estra-4,9-dien-3-one
有权
中孕素11和bgr的固体形式 - {4E-（羟基亚氨基甲基） - 苯基}-17α甲氧基甲基-17β-甲氧基 - 雌-4,9-二烯-3-酮
- Patent Title: Solid body forms of mesoprogestin 11β-{4E-(hydroxyiminomethyl)-phenyl}-17α methoxymethyl-17β-methoxy-estra-4,9-dien-3-one
- Patent Title (中): 中孕素11和bgr的固体形式 - {4E-（羟基亚氨基甲基） - 苯基}-17α甲氧基甲基-17β-甲氧基 - 雌-4,9-二烯-3-酮
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Application No.: US10296463Application Date: 2001-05-09
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Publication No.: US07799770B2Publication Date: 2010-09-21
- Inventor: Detlef Grawe , Peter Hosel , Uwe Muller , Gabriele Winter
- Applicant: Detlef Grawe , Peter Hosel , Uwe Muller , Gabriele Winter
- Applicant Address: DE Berlin
- Assignee: Bayer Schering Pharma AG
- Current Assignee: Bayer Schering Pharma AG
- Current Assignee Address: DE Berlin
- Agency: Millen, White, Zelano, Branigan, P.C.
- Priority: EP00110887 20000523
- International Application: PCT/EP01/05237 WO 20010509
- International Announcement: WO01/90137 WO 20011129
- Main IPC: A61K31/56
- IPC: A61K31/56 ; C07J1/00
Abstract:
The invention relates to novel solid body forms of mesoprogestin 11β-[4E-(hydroxyiminomethyl)-phenyl]-17α-methoxymethyl-17β-methoxy-estra-4,9-dien-3-one (oxime J 867), particularly a highly pure and stable amorphous or highly crystalline form (ansolvate/anhydrate) of compound J 867. The invention also relates to methods for producing said novel solid body forms and to the use thereof in pharmaceutical compositions. The novel solid body forms are characterized by exhibiting a high degree of stability. The solid body forms of oxime J 867 can, in particular, be used in the area of fertility control and in hormone replacement therapy.
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