Invention Grant
US07799787B2 Heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase
失效
杂芳族化合物作为硬脂酰辅酶A-9去饱和酶的抑制剂
- Patent Title: Heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase
- Patent Title (中): 杂芳族化合物作为硬脂酰辅酶A-9去饱和酶的抑制剂
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Application No.: US12086023Application Date: 2006-12-18
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Publication No.: US07799787B2Publication Date: 2010-09-21
- Inventor: Denis Deschenes , Rejean Fortin , Chun Sing Li , Renata M. Oballa , Yeeman K. Ramtohul
- Applicant: Denis Deschenes , Rejean Fortin , Chun Sing Li , Renata M. Oballa , Yeeman K. Ramtohul
- Applicant Address: CA Quebec
- Assignee: Merck Frosst Canada Ltd.
- Current Assignee: Merck Frosst Canada Ltd.
- Current Assignee Address: CA Quebec
- Agent Philippe L. Durette; John C. Todaro
- International Application: PCT/CA2006/002053 WO 20061218
- International Announcement: WO2007/071023 WO 20070628
- Main IPC: C07D401/04
- IPC: C07D401/04 ; A61K31/501 ; A61P9/00 ; A61P9/10 ; A61P35/00 ; A61P3/10 ; A61P3/04 ; A61P3/00 ; A61P1/16
Abstract:
Heteroaromatic compounds of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; lipid disorders; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; fatty liver disease and cancer.
Public/Granted literature
- US20090088431A1 Heteroaromatic Compounds as Inhibitors of Stearoyl-Coenzyme a Delta-9 Desaturase Public/Granted day:2009-04-02
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