Signal compensation systems and methods. The system comprises a sensor and a processing module. The sensor detects movements of a camera device to generate sensed signals. The processing module acquires a relative maximum value and a relative minimum value of the sensed signals, and calculates an absolute difference accordingly. The absolute difference is the absolute value of the relative maximum value added the relative minimum value. The processing module determines whether the absolute difference exceeds a predetermined value. If so, the sensed signals are identified with a drift, and compensated according to the absolute difference.