An optical drive servo control system comprises: an optical pickup, for accessing an optical disc and generating an optical signal; a spindle motor, for rotating the optical disc and outputting a FG signal and a spindle motor synchronous signal; a frequency-multiplied FG signal generator, for generating an actual frequency-multiplied FG signal after receiving the FG signal, the spindle motor synchronous signal, a reference clock signal, and a frequency-multiplier value; and, a servo control unit, for controlling the spindle motor and the optical pickup, and compensating a run-out error of the optical disc according to the actual frequency-multiplied FG signal; wherein the frequency-multiplied FG signal generator calculates an ideal frequency-multiplied FG signal according to the reference clock signal and the frequency-multiplier value, and a positioning error between the ideal frequency-multiplied FG signal and the actual frequency-multiplied FG signal is less than half of a period of the reference clock signal.