A system and method for canceling interference over a group of signals. One or more wires in a group of wires are designated to carry one or more reference signals. The one or more reference signals are used to cancel interference from the data carrying signals in the group of signals. Preferably, the one or more reference signals are subtracted from the data carrying signals to cancel interference from the data carrying signals. Analog or digital elements can be used to subtract the one or more reference signals from the data carrying signals. For example, an operation amplifier or a DSP may be used to perform the subtraction. Filters may be used to further adapt the one or more reference signals prior to the subtracting step to optimize interference cancellation. The filters may be either digital or analog.