Invention Grant
- Patent Title: Artificial low-density lipoprotein carriers for transport of substances across the blood-brain barrier
-
Application No.: US11802727Application Date: 2007-05-24
-
Publication No.: US07803400B2Publication Date: 2010-09-28
- Inventor: Thomas J. Nelson , Daniel L. Alkon , Alessandro Quattrone
- Applicant: Thomas J. Nelson , Daniel L. Alkon , Alessandro Quattrone
- Applicant Address: US WV Morgantown
- Assignee: Blanchette Rockefeller Neurosciences Institute
- Current Assignee: Blanchette Rockefeller Neurosciences Institute
- Current Assignee Address: US WV Morgantown
- Agency: Milbank, Tweed, Hadley & McCloy LLP
- Main IPC: A61K9/14
- IPC: A61K9/14 ; A61K31/195 ; A61K38/02 ; A61P43/00
Abstract:
This invention relates to a highly efficient artificial low-density lipoprotein (LDL) carrier system for the targeted delivery therapeutic agents across the blood-brain barrier (BBB). In particular, this invention relates to artificial LDL particles comprised of three lipid elements: phosphatidyl choline, fatty-acyl-cholesterol esters, and at least one apolipoprotein. The present invention further relates to compositions, methods and kits comprising artificial LDL particles for targeting drugs to and across the BBB for the prevention and treatment of brain diseases.
Public/Granted literature
- US20080160094A1 Artificial low-density lipoprotein carriers for transport of substances across the blood-brain barrier Public/Granted day:2008-07-03
Information query
