Invention Grant
US07803553B2 Methods of use of antibodies which recognize a protease cleavage site of an LAP fragment of TGF-β
有权
识别TGF-β的LAP片段的蛋白酶切割位点的抗体的使用方法
- Patent Title: Methods of use of antibodies which recognize a protease cleavage site of an LAP fragment of TGF-β
- Patent Title (中): 识别TGF-β的LAP片段的蛋白酶切割位点的抗体的使用方法
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Application No.: US10570606Application Date: 2004-09-03
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Publication No.: US07803553B2Publication Date: 2010-09-28
- Inventor: Soichi Kojima , Naoshi Dohmae , Wakako Kondo
- Applicant: Soichi Kojima , Naoshi Dohmae , Wakako Kondo
- Applicant Address: JP Saitama
- Assignee: RIKEN
- Current Assignee: RIKEN
- Current Assignee Address: JP Saitama
- Agency: Greenblum & Bernstein, P.L.C.
- Priority: JP2003-313014 20030904
- International Application: PCT/JP2004/013189 WO 20040903
- International Announcement: WO2005/023870 WO 20050317
- Main IPC: G01N33/53
- IPC: G01N33/53
Abstract:
It is an object of the present invention to provide antibodies capable of detecting an active TGF-β generation reaction that is specific to pathogenesis, tissues, or isoforms. The present invention provides antibodies against an LAP fragment (or latent TGF-β) generated as a result of generation of active form of human TGF-β1, human TGOF-β2 and human TGF-β3. The antibodies are able to specifically recognize respective cutting edges within protease cleavage sites existing in the region from the amino acid residue glycine at position 51 to the amino acid residue arginine at position 110 of human TGF-β1, and corresponding regions of human TGF-β2 and human TGF-β3.
Public/Granted literature
- US20080038748A1 Antibodies That Recognize Cutting Edge Within The Tgf-Beta Activation Controlling Region Public/Granted day:2008-02-14
Information query
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