Invention Grant
US07803566B2 Identification of gene sequences and proteins involved in vaccinia virus dominant T cell epitopes
有权
鉴定参与痘苗病毒显性T细胞表位的基因序列和蛋白质
- Patent Title: Identification of gene sequences and proteins involved in vaccinia virus dominant T cell epitopes
- Patent Title (中): 鉴定参与痘苗病毒显性T细胞表位的基因序列和蛋白质
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Application No.: US11731784Application Date: 2007-03-30
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Publication No.: US07803566B2Publication Date: 2010-09-28
- Inventor: Masanori Terajima , John Cruz , Francis A. Ennis
- Applicant: Masanori Terajima , John Cruz , Francis A. Ennis
- Applicant Address: US MA Boston
- Assignee: The University of Massachusetts
- Current Assignee: The University of Massachusetts
- Current Assignee Address: US MA Boston
- Agency: Hamilton, Brook, Smith & Reynolds, P.C.
- Main IPC: G01N33/53
- IPC: G01N33/53 ; C07K5/00
Abstract:
The present invention relates to the identification of gene sequences and proteins involved in vaccinia virus dominant T cell epitopes. Two vaccinia virus CD8+ T cell epitopes restricted by the most common human MHC class I allele, HLA-A0201 have been identified. Both epitopes are highly conserved in vaccinia and variola viruses. The induction of the T cell responses following primary vaccination is demonstrated by the kinetics of epitope specific CD8+ T cells in 3 HLA-A0201 individuals. This information will be useful for the design and analyses of the immunogenicity of experimental vaccinia vaccines, and for basic studies of human T cell memory.
Public/Granted literature
- US20070298046A1 Identification of gene sequences and proteins involved in vaccinia virus dominant T cell epitopes Public/Granted day:2007-12-27
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