Invention Grant
- Patent Title: Method for overexpression of zwitterionic polysaccharides
- Patent Title (中): 两性离子多糖过表达方法
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Application No.: US11894552Application Date: 2007-08-20
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Publication No.: US07803602B2Publication Date: 2010-09-28
- Inventor: Laurie E. Comstock , Katja G. Weinacht , Michael J. Coyne , Dennis L. Kasper , Arthur O. Tzianabos
- Applicant: Laurie E. Comstock , Katja G. Weinacht , Michael J. Coyne , Dennis L. Kasper , Arthur O. Tzianabos
- Applicant Address: US MA Boston
- Assignee: The Brigham and Woman's Hospital, Inc.
- Current Assignee: The Brigham and Woman's Hospital, Inc.
- Current Assignee Address: US MA Boston
- Agency: Wolf, Greenfield & Sacks, P.C.
- Main IPC: C12N1/20
- IPC: C12N1/20 ; C12N15/87 ; C12N15/74 ; C12P21/06 ; C12P19/04 ; C12P19/34 ; A01N63/00
Abstract:
The present invention is directed to methods for producing and selecting new mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; compositions directed to the new mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; improved methods for purification of individual capsular polysaccharides; and compositions directed to new res02 and inv19 genes and their gene products. Significantly, the present invention provides methods and compositions for overexpressing and purifying immunomodulatory capsular polysaccharide A (PSA) in high yield.
Public/Granted literature
- US20080057565A1 Method for overexpression of zwitterionic polysaccharides Public/Granted day:2008-03-06
Information query
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