Invention Grant
US07803614B2 Melanoma antigens and their use in diagnostic and therapeutic methods
有权
黑素瘤抗原及其在诊断和治疗方法中的应用
- Patent Title: Melanoma antigens and their use in diagnostic and therapeutic methods
- Patent Title (中): 黑素瘤抗原及其在诊断和治疗方法中的应用
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Application No.: US11932255Application Date: 2007-10-31
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Publication No.: US07803614B2Publication Date: 2010-09-28
- Inventor: Yutaka Kawakami , Steven A. Rosenberg
- Applicant: Yutaka Kawakami , Steven A. Rosenberg
- Applicant Address: US DC Washington
- Assignee: The United States of America as represented by the Department of Health and Human Services
- Current Assignee: The United States of America as represented by the Department of Health and Human Services
- Current Assignee Address: US DC Washington
- Agency: Leydig, Voit & Mayer
- Main IPC: C12N15/00
- IPC: C12N15/00
Abstract:
The present invention provides a nucleic acid sequence encoding a melanoma antigen recognized by T lymphocytes, designated MART-1. This invention further relates to bioassays using the nucleic acid sequence, protein or antibodies of this invention to diagnose, assess or prognoses a mammal afflicted with melanoma or metastata melanoma. This invention also provides immunogenic peptides derived from the MRT-1 melanoma antigen and a second melanoma antigen designated gp100. This invention further provides immunogenic peptides derived from the MART-1 melanoma antigen or gp100 antigen which have been modified to enhance their immunogenicity. The proteins and peptides provided can serve as an immunogen or vaccine to prevent or treat melanoma.
Public/Granted literature
- US20080233637A1 MELANOMA ANTIGENS AND THEIR USE IN DIAGNOSTIC AND THERAPEUTIC METHODS Public/Granted day:2008-09-25
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