Invention Grant
US07803831B2 3-(2-hydroxy-phenyl)-1H-pyrazole-4-carboxylic acid amide derivatives as HSP90 inhibitors for the treatment of cancer
失效
3-（2-羟基 - 苯基）-1H-吡唑-4-羧酸酰胺衍生物作为治疗癌症的HSP90抑制剂
- Patent Title: 3-(2-hydroxy-phenyl)-1H-pyrazole-4-carboxylic acid amide derivatives as HSP90 inhibitors for the treatment of cancer
- Patent Title (中): 3-（2-羟基 - 苯基）-1H-吡唑-4-羧酸酰胺衍生物作为治疗癌症的HSP90抑制剂
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Application No.: US10536898Application Date: 2003-12-04
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Publication No.: US07803831B2Publication Date: 2010-09-28
- Inventor: Mandy Christine Beswick , Paul Andrew Brough , Martin James Drysdale , Brian William Dymock
- Applicant: Mandy Christine Beswick , Paul Andrew Brough , Martin James Drysdale , Brian William Dymock
- Applicant Address: GB GB GB
- Assignee: Vernalis (Cambridge) Limited,Cancer Research Technology Ltd.,Institute Of Cancer Research
- Current Assignee: Vernalis (Cambridge) Limited,Cancer Research Technology Ltd.,Institute Of Cancer Research
- Current Assignee Address: GB GB GB
- Agency: Banner & Witcoff, Ltd.
- Priority: GB0228417.2 20021205
- International Application: PCT/GB03/05275 WO 20031204
- International Announcement: WO2004/050087 WO 20040617
- Main IPC: A61K31/415
- IPC: A61K31/415 ; A61K31/4155 ; C07D401/12 ; C07D403/12
Abstract:
Compounds of formula (IA) or (IB) or salts, N-oxides, hydrates or solvates thereof are Inhibitors of HSP90, and useful in the treatment of, for example, cancer: formula (IA), formula (IB) wherein Ar is an aryl or heteroaryl radical which is linked via a ring carbon, and which is substituted by a hydroxy group on a carbon in the 2-position, and which is otherwise either unsubstituted or optionally substituted; R1 is hydrogen or optionally substituted C1-C6 alkyl; R2 is hydrogen, optionally substituted cycloalkyl, cycloalkenyl, C1-C6 alkyl, C1-C6alkenyl, or C1-C6 alkynyl; or a carboxyl, carboxamide or carboxyl ester group; and R3 is a carboxamide group.
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