Invention Grant
US07803913B2 Identification of novel broadly cross-reactive neutralizing human monoclonal antibodies using sequential antigen panning of phage display libraries
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使用噬菌体展示文库的顺序抗原淘选来鉴定新的广泛交叉反应性中和人单克隆抗体
- Patent Title: Identification of novel broadly cross-reactive neutralizing human monoclonal antibodies using sequential antigen panning of phage display libraries
- Patent Title (中): 使用噬菌体展示文库的顺序抗原淘选来鉴定新的广泛交叉反应性中和人单克隆抗体
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Application No.: US10513725Application Date: 2003-05-06
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Publication No.: US07803913B2Publication Date: 2010-09-28
- Inventor: Dimiter S Dimitrov , Mei-Yun Zhang
- Applicant: Dimiter S Dimitrov , Mei-Yun Zhang
- Applicant Address: US DC Washington
- Assignee: The United States of America as represented by the Department of Health and Human Services
- Current Assignee: The United States of America as represented by the Department of Health and Human Services
- Current Assignee Address: US DC Washington
- Agency: Leydig, Voit & Mayer, Ltd.
- International Application: PCT/US03/14292 WO 20030506
- International Announcement: WO03/092630 WO 20031113
- Main IPC: C07K16/00
- IPC: C07K16/00 ; A61K39/42
Abstract:
The present invention provides a method of identifying novel broadly crossreactive neutralizing monoclonal antibodies using sequential antigen panning of phage display libraries, antibodies obtained in accordance with such a method, as well as fusion proteins and conjugates comprising same, and related isolated or purified nucleic acid molecules, vectors, host cells, compositions, and methods of use to inhibit an infection, reduce the severity of an infection, treat an infection, and inhibit cancer.
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