Invention Grant
- Patent Title: Polynucleotides encoding myostatin binding agents
- Patent Title (中): 编码肌肉生长抑制素结合剂的多核苷酸
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Application No.: US12322369Application Date: 2009-01-30
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Publication No.: US07803923B2Publication Date: 2010-09-28
- Inventor: Hq Han , Hosung Min , Thomas C. Boone
- Applicant: Hq Han , Hosung Min , Thomas C. Boone
- Applicant Address: US CA Thousand Oaks
- Assignee: Amgen Inc.
- Current Assignee: Amgen Inc.
- Current Assignee Address: US CA Thousand Oaks
- Agent Christine M. Bellas
- Main IPC: C12N15/11
- IPC: C12N15/11 ; C12N15/62 ; C12N15/63 ; C12N1/11 ; C12N1/15 ; C12N1/21 ; C12N5/10
Abstract:
The present invention provides binding agents comprising peptides capable of binding myostatin and inhibiting its activity. In one embodiment the binding agent comprises at least one myostatin-binding peptide attached directly or indirectly to at least one vehicle such as a polymer or an Fc domain. The binding agents of the present invention produced increased lean muscle mass when administered to animals and decreased fat to muscle ratios. Therapeutic compositions containing the binding agents of the present invention are useful for treating muscle-wasting disorders and metabolic disorders including diabetes and obesity.
Public/Granted literature
- US20090227517A1 Myostatin binding agents Public/Granted day:2009-09-10
Information query
IPC分类:
