Invention Grant
US07803929B2 Kits for diagnosis and monitoring of pathogenic infection by analysis of cell-free pathogenic nucleic acids in urine
有权
通过分析尿液中无细胞致病性核酸的病原体感染诊断和监测试剂盒
- Patent Title: Kits for diagnosis and monitoring of pathogenic infection by analysis of cell-free pathogenic nucleic acids in urine
- Patent Title (中): 通过分析尿液中无细胞致病性核酸的病原体感染诊断和监测试剂盒
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Application No.: US11137934Application Date: 2005-05-25
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Publication No.: US07803929B2Publication Date: 2010-09-28
- Inventor: Hovsep Melkonyan , Angela Cannas , Louis David Tomei , Samuil R. Umansky
- Applicant: Hovsep Melkonyan , Angela Cannas , Louis David Tomei , Samuil R. Umansky
- Applicant Address: US CA San Diego
- Assignee: TrovaGene, Inc.
- Current Assignee: TrovaGene, Inc.
- Current Assignee Address: US CA San Diego
- Agency: Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.
- Agent Ivor R. Elrifi; Matthew Pavao
- Priority: ITRM2005A0068 20050217
- Main IPC: C07H21/04
- IPC: C07H21/04 ; A61K9/14 ; C12N9/12
Abstract:
The present invention relates to a method for diagnosing and/or monitoring a bacterial or parasitic infection by detection and quantification of the transrenal nucleic acids, derived from bacterial pathogenic agents or from parasites, in urine. The detection method optionally includes the isolation and the purification of the nucleic acids from urine by methods known in the art including pairing with molecular probes that are specific for the pathogenic agents, PCR hybridization, PCR, nested PCR, SSCP, LCR, and SDA. Diagnostic kits based on these detection methods are also claimed.
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